I always start with the eyes, then the nose, and they’re just fine after voxel remesh many times. But when I’m working on the lips, it’s always ending up like this.
In case it’s not a layer issue, small polygons produce “pointyness” when smoothing. There’s a “stable smoothing” switch in the smooth options which might improve things.
You can also try smoothing with DynTopo on, it makes the polygons more regular so they smooth in a rounder way.
So when you voxel remesh e.g. two meshes with layers to one mesh, then the layers will also be merged, and if you sculpt then on the wrong layer, e.g. smoothing doesn’t work…